Antipsychotic Drug Trifluoperazine Suppresses Colorectal Cancer by Inducing G0/G1 Arrest and Apoptosis

• Main Authors: Yong Xia (Author), Chengsen Jia (Author), Qiang Xue (Author), Jinrui Jiang (Author), Yao Xie (Author), Ranran Wang (Author), Zhiqiang Ran (Author), Fuyan Xu (Author), Yiwen Zhang (Author), Tinghong Ye (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Repurposing existing drugs for cancer treatment is an effective strategy. An approved antipsychotic drug, trifluoperazine (TFP), has been reported to have potential anticancer effects against several cancer types. Here, we investigated the effect and molecular mechanism of TFP in colorectal cancer (...