One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics

• 主要な著者: Wei Chen (著者), Fan Yang (著者), Carole Wang (著者), Jatin Narula (著者), Edward Pascua (著者), Irene Ni (著者), Sheng Ding (著者), Xiaodi Deng (著者), Matthew Ling-Hon Chu (著者), Amber Pham (著者), Xiaoyue Jiang (著者), Kevin C. Lindquist (著者), Patrick J. Doonan (著者), Tom Van Blarcom (著者), Yik Andy Yeung (著者), Javier Chaparro-Riggers (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

T-cell engaging biologics is a class of novel and promising immune-oncology compounds that leverage the immune system to eradicate cancer. Here, we compared and contrasted a bispecific diabody-Fc format, which displays a relatively short antigen-binding arm distance, with our bispecific IgG platform...