Pre-treatment of the beta3-adrenergic receptor agonist BRL37344 reduces in vivo myocardial ischemia/reperfusion injury by improving AMPK and SIRT1 activity and by suppressing mTOR and p70S6K signaling pathways

• Main Authors: Dilan Askin Ozek (Author), Elif Onat (Author), Kazim Sahin (Author), Mehmet Tuzcu (Author), Merve Yilmaz Bozoglan (Author), Engin Sahna (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This study aimed to investigate the role and signaling pathways of β3-AR in myocardial ischemia/reperfusion (I/R) injury, which is one of the leading causes of death worldwide. 47 male rats were randomly divided into two main groups to evaluate infarct size and molecular parameters. Rats in...