A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients

• मुख्य लेखकों: Alexia Chauzy (लेखक), Salim Bouchène (लेखक), Vincent Aranzana-Climent (लेखक), Jonathan Clarhaut (लेखक), Christophe Adier (लेखक), Nicolas Grégoire (लेखक), William Couet (लेखक), Claire Dahyot-Fizelier (लेखक), Sandrine Marchand (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Understanding antibiotic concentration-time profiles in the central nervous system (CNS) is crucial to treat severe life-threatening CNS infections, such as nosocomial ventriculitis or meningitis. Yet CNS distribution is likely to be altered in patients with brain damage and infection/inflammation....