A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients
Understanding antibiotic concentration-time profiles in the central nervous system (CNS) is crucial to treat severe life-threatening CNS infections, such as nosocomial ventriculitis or meningitis. Yet CNS distribution is likely to be altered in patients with brain damage and infection/inflammation....
Saved in:
Main Authors: | Alexia Chauzy (Author), Salim Bouchène (Author), Vincent Aranzana-Climent (Author), Jonathan Clarhaut (Author), Christophe Adier (Author), Nicolas Grégoire (Author), William Couet (Author), Claire Dahyot-Fizelier (Author), Sandrine Marchand (Author) |
---|---|
Format: | Book |
Published: |
MDPI AG,
2022-09-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria
by: Alexia Chauzy, et al.
Published: (2019) -
PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo
by: Alexia Chauzy, et al.
Published: (2022) -
Contribution of CNS cells in NeuroAIDS
by: Ashish Swarup Verma, et al.
Published: (2010) -
Neuro-Immune Connections to Enable Repair in CNS Disorders
Published: (2020) -
Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery
by: Frédéric Tewes, et al.
Published: (2020)