A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients

• Main Authors: Alexia Chauzy (Author), Salim Bouchène (Author), Vincent Aranzana-Climent (Author), Jonathan Clarhaut (Author), Christophe Adier (Author), Nicolas Grégoire (Author), William Couet (Author), Claire Dahyot-Fizelier (Author), Sandrine Marchand (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Understanding antibiotic concentration-time profiles in the central nervous system (CNS) is crucial to treat severe life-threatening CNS infections, such as nosocomial ventriculitis or meningitis. Yet CNS distribution is likely to be altered in patients with brain damage and infection/inflammation....