Modeling human pancreatic beta cell dedifferentiation

• Main Authors: Marc Diedisheim (Author), Masaya Oshima (Author), Olivier Albagli (Author), Charlotte Wennberg Huldt (Author), Ingela Ahlstedt (Author), Maryam Clausen (Author), Suraj Menon (Author), Alexander Aivazidis (Author), Anne-Christine Andreasson (Author), William G. Haynes (Author), Piero Marchetti (Author), Lorella Marselli (Author), Mathieu Armanet (Author), Fabrice Chimienti (Author), Raphael Scharfmann (Author)
• Format: Book
• Published: Elsevier, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). Methods: Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pancreatic islets. Results: Fibroblast growth factor 2 (...