Inhibition of VDAC1 Rescues Aβ1-42-Induced Mitochondrial Dysfunction and Ferroptosis via Activation of AMPK and Wnt/β-Catenin Pathways

• Main Authors: Xinpei Zhou (Author), Ximin Tang (Author), Tao Li (Author), Dandan Li (Author), Zhiting Gong (Author), Xiujun Zhang (Author), Yanjiao Li (Author), Jianhua Zhu (Author), Yong Wang (Author), Bensi Zhang (Author)
• Format: Book
• Published: Hindawi Limited, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Beta-amyloid (Aβ) accumulation in the brains of Alzheimer's disease (AD) patients leads to mitochondrial dysfunction and ferroptosis in neurons. Voltage-dependent anion channel 1 (VDAC1) is a major protein in the mitochondrial outer membrane. It has been reported that VDAC1 associated with mito...