Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

• Main Authors: Thomas W von Geldern (Author), Howard E Morton (Author), Rick F Clark (Author), Brian S Brown (Author), Kelly L Johnston (Author), Louise Ford (Author), Sabine Specht (Author), Robert A Carr (Author), Deanne F Stolarik (Author), Junli Ma (Author), Matthew J Rieser (Author), Dominique Struever (Author), Stefan J Frohberger (Author), Marianne Koschel (Author), Alexandra Ehrens (Author), Joseph D Turner (Author), Marc P Hübner (Author), Achim Hoerauf (Author), Mark J Taylor (Author), Stephen A Ward (Author), Kennan Marsh (Author), Dale J Kempf (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substantially augment the benefits of mass drug administrat...