Inducible SMARCAL1 knockdown in iPSC reveals a link between replication stress and altered expression of master differentiation genes

• Main Authors: Giusj Monia Pugliese (Author), Federico Salaris (Author), Valentina Palermo (Author), Veronica Marabitti (Author), Nicolò Morina (Author), Alessandro Rosa (Author), Annapaola Franchitto (Author), Pietro Pichierri (Author)
• Format: Book
• Published: The Company of Biologists, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schimke immuno-osseous dysplasia is an autosomal recessive genetic osteochondrodysplasia characterized by dysmorphism, spondyloepiphyseal dysplasia, nephrotic syndrome and frequently T cell immunodeficiency. Several hypotheses have been proposed to explain the pathophysiology of the disease; however...