Lipid Nanoparticle-mediated siRNA Transfer Against PCTAIRE1/PCTK1/Cdk16 Inhibits In Vivo Cancer Growth

• Main Authors: Teruki Yanagi (Author), Kiyoshi Tachikawa (Author), Rachel Wilkie-Grantham (Author), Asami Hishiki (Author), Ko Nagai (Author), Ellen Toyonaga (Author), Pad Chivukula (Author), Shu-ichi Matsuzawa (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PCTAIRE1/CDK16/PCTK1 plays critical roles in cancer cell proliferation and antiapoptosis. To advance our previously published in vitro results with PCTAIRE1 silencing, we examined the in vivo therapeutic potential of this approach by using small interfering RNA (siRNA) encapsulated by lipid nanopart...