Secondary Buruli ulcer skin lesions emerging several months after completion of chemotherapy: paradoxical reaction or evidence for immune protection?

• Main Authors: Marie-Thérèse Ruf (Author), Annick Chauty (Author), Ambroise Adeye (Author), Marie-Françoise Ardant (Author), Hugues Koussemou (Author), Roch Christian Johnson (Author), Gerd Pluschke (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The neglected tropical disease Buruli ulcer (BU) caused by Mycobacterium ulcerans is an infection of the subcutaneous tissue leading to chronic ulcerative skin lesions. Histopathological features are progressive tissue necrosis, extracellular clusters of acid fast bacilli (AFB) and poor...