Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in <i>Xenopus Laevis</i> Oocytes

• मुख्य लेखकों: James Cobley (लेखक), Anna Noble (लेखक), Rachel Bessell (लेखक), Matthew Guille (लेखक), Holger Husi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2020-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Oocytes are postulated to repress the proton pumps (e.g., complex IV) and ATP synthase to safeguard mitochondrial DNA homoplasmy by curtailing superoxide production. Whether the ATP synthase is inhibited is, however, unknown. Here we show that: oligomycin sensitive ATP synthase activity is significa...