Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in <i>Xenopus Laevis</i> Oocytes

• 主要な著者: James Cobley (著者), Anna Noble (著者), Rachel Bessell (著者), Matthew Guille (著者), Holger Husi (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2020-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Oocytes are postulated to repress the proton pumps (e.g., complex IV) and ATP synthase to safeguard mitochondrial DNA homoplasmy by curtailing superoxide production. Whether the ATP synthase is inhibited is, however, unknown. Here we show that: oligomycin sensitive ATP synthase activity is significa...