Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus

• Main Authors: Celina Uhlemeyer (Author), Nadine Müller (Author), Michael Rieck (Author), Jennifer Kuboth (Author), Caroline Schlegel (Author), Kerstin Grieß (Author), Tim Florian Dorweiler (Author), Sonja Heiduschka (Author), Jürgen Eckel (Author), Michael Roden (Author), Eckhard Lammert (Author), Markus Stoffel (Author), Bengt-Frederik Belgardt (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Beta cell dysfunction and death are critical steps in the development of both type 1 and type 2 diabetes (T1D and T2D), but the underlying mechanisms are incompletely understood. Activation of the essential tumor suppressor and transcription factor P53 (also known as TP53 and Trp53 in mic...