Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

• Main Authors: Sara Chiappalupi (Author), Guglielmo Sorci (Author), Aleksandra Vukasinovic (Author), Laura Salvadori (Author), Roberta Sagheddu (Author), Dario Coletti (Author), Giorgia Renga (Author), Luigina Romani (Author), Rosario Donato (Author), Francesca Riuzzi (Author)
• Format: Book
• Published: Wiley, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer‐associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy caused by systemic inflammation is a...