Overexpression of thioredoxin‐2 attenuates age‐related muscle loss by suppressing mitochondrial oxidative stress and apoptosis

• Main Authors: Huibin Tang (Author), Michael Kim (Author), Myung Lee (Author), Kellie Baumann (Author), Francesca Olguin (Author), Hao He (Author), Yoyo Wang (Author), Bowen Jiang (Author), Shuhuan Fang (Author), Jinguo Zhu (Author), Kun Wang (Author), Hui Xia (Author), Yang Gao (Author), Harrison B. Konsker (Author), Emmanuel A. Fatodu (Author), Marco Quarta (Author), Justin Blonigan (Author), Thomas A. Rando (Author), Joseph B. Shrager (Author)
• Format: Book
• Published: Wiley, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Skeletal muscle mass is regulated by intracellular anabolic and catabolic activities. Increased catabolic activity can shift the balance towards net protein breakdown and muscle atrophy. Mitochondrial oxidative stress activates catabolism and is linked to muscle loss. Reducing mi...