Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.

• Main Authors: James A Thomas (Author), Nicola Baker (Author), Sebastian Hutchinson (Author), Caia Dominicus (Author), Anna Trenaman (Author), Lucy Glover (Author), Sam Alsford (Author), David Horn (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemotherapy continues to have a major impact on reducing the burden of disease caused by trypanosomatids. Unfortunately though, the mode-of-action (MoA) of antitrypanosomal drugs typically remains unclear or only partially characterised. This is the case for four of five current drugs used to treat...