LPS activates neuroinflammatory pathways to induce depression in Parkinson's disease-like condition

• Main Authors: Jing Zhang (Author), Bing Xue (Author), Bin Jing (Author), Huiling Tian (Author), Naiwen Zhang (Author), Mengyuan Li (Author), Lihua Lu (Author), Lin Chen (Author), Huaqiong Diao (Author), Yufei Chen (Author), Min Wang (Author), Xiaoli Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: This study aimed to observe the effects of lipopolysaccharide (LPS) intraperitoneal (i.p.) injection on rats and investigate how neuroinflammation contributes to the pathogenesis of depression in Parkinson's disease (dPD).Methods: Rats were administered LPS (0.5 mg/kg, i.p.) for either 1,...