Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K+ channels

• Main Authors: Kensuke Sakakibara (Author), Guo-Gang Feng (Author), Jiazheng Li (Author), Takahiko Akahori (Author), Yoshitaka Yasuda (Author), Emi Nakamura (Author), Noboru Hatakeyama (Author), Yoshihiro Fujiwara (Author), Hiroyuki Kinoshita (Author)
• Format: Book
• Published: Elsevier, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Kynurenine is a potential contributor to hypotension in animal and human sepsis. The present study was designed to examine whether the voltage-dependent K+ channels encoded by the KCNQ gene family (Kv7 channels) mediate vasodilator effects of kynurenine and whether modulation of these channels ameli...