Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

• Main Authors: Araceli Lérida-Viso (Author), Alejandra Estepa- Fernández (Author), Ángela Morellá-Aucejo (Author), Beatriz Lozano-Torres (Author), María Alfonso (Author), Juan F. Blandez (Author), Viviana Bisbal (Author), Pilar Sepúlveda (Author), Alba García-Fernández (Author), Mar Orzáez (Author), Ramón Martínez-Máñez (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Many anticancer agents used in clinics induce premature senescence in healthy tissues generating accelerated aging processes and adverse side-effects in patients. Cardiotoxicity is a well-known limiting factor of anticancer treatment with doxorubicin (DOX), a very effective anthracycline widely used...