Synthesis and activity of novel indole derivatives as inhibitors of CD38

• Main Authors: Dongying Wu (Author), Kaiyiu Ting (Author), Yaokai Duan (Author), Na Li (Author), Jianguo Li (Author), Liangren Zhang (Author), Honcheung Lee (Author), Lihe Zhang (Author)
• Format: Book
• Published: Elsevier, 2013-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CD38 is a multifunctional enzyme/receptor expressed in a variety of mammalian tissues, regulating a wide range of physiological functions. Beginning with the previously reported compound 1, an inhibitor of human CD38 NADase, we synthesized a series of indole-based NH-substituted derivatives with mod...