Diminished perisomatic GABAergic terminals on cortical neurons adjacent to amyloid plaques

• Main Authors: Virginia Garcia-Marin (Author), Lidia Blazquez-Llorca (Author), José-Rodrigo Rodriguez (Author), Susana Boluda (Author), Gerard Muntane (Author), Isidro Ferrer (Author), Javier DeFelipe (Author)
• Format: Book
• Published: Frontiers Media S.A., 2009-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One of the main pathological hallmarks of Alzheimer’s disease (AD) is the accumulation of plaques in the cerebral cortex, which may appear either in the neuropil or in direct association with neuronal somata. Since different axonal systems innervate the dendritic (mostly glutamatergic) and perisomat...