Improving the Repeatability and Efficacy of Intradermal Electroporated Self-Replicating mRNA

• Main Authors: Hanne Huysmans (Author), Joyca De Temmerman (Author), Zifu Zhong (Author), Séan Mc Cafferty (Author), Francis Combes (Author), Freddy Haesebrouck (Author), Niek N. Sanders (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Local administration of naked self-replicating mRNA (sr-mRNA) in the skin or muscle using electroporation is effective but hampered by low repeatability. In this manuscript, we demonstrated that intradermal electroporation of sr-mRNA in combination with a protein-based RNase inhibitor increased the...