The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1

• Main Authors: Xinyuan Xu (Author), Yingyi Chen (Author), Qiang Fu (Author), Duan Ni (Author), Jian Zhang (Author), Xiaolong Li (Author), Shaoyong Lu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phosphoinositide-dependent protein kinase-1 (PDK1) is an important protein in mediating the PI3K-AKT pathway and is thus identified as a promising target. The catalytic activity of PDK1 is tightly regulated by allosteric modulators, which bind to the PDK1 Interacting Fragment (PIF) pocket of the kin...