The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1

Phosphoinositide-dependent protein kinase-1 (PDK1) is an important protein in mediating the PI3K-AKT pathway and is thus identified as a promising target. The catalytic activity of PDK1 is tightly regulated by allosteric modulators, which bind to the PDK1 Interacting Fragment (PIF) pocket of the kin...

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Principais autores: Xinyuan Xu (Autor), Yingyi Chen (Autor), Qiang Fu (Autor), Duan Ni (Autor), Jian Zhang (Autor), Xiaolong Li (Autor), Shaoyong Lu (Autor)
Formato: Livro
Publicado em: Taylor & Francis Group, 2019-01-01T00:00:00Z.
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3rd Floor Main Library

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