The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1
Phosphoinositide-dependent protein kinase-1 (PDK1) is an important protein in mediating the PI3K-AKT pathway and is thus identified as a promising target. The catalytic activity of PDK1 is tightly regulated by allosteric modulators, which bind to the PDK1 Interacting Fragment (PIF) pocket of the kin...
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Principais autores: | , , , , , , |
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Formato: | Livro |
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Taylor & Francis Group,
2019-01-01T00:00:00Z.
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Número de Chamada: |
A1234.567 |
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Cópia 1 | Disponível |