Allopurinol Lowers Serum Urate but Does Not Reduce Oxidative Stress in CKD

• Main Authors: Mingyao Sun (Author), Nicole Hines (Author), Diego Scerbo (Author), Jane Buchanan (Author), Chaorong Wu (Author), Patrick Ten Eyck (Author), Diana Zepeda-Orozco (Author), Eric B. Taylor (Author), Diana I. Jalal (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Xanthine oxidase (XO) contributes to oxidative stress and vascular disease. Hyperuricemia and gout are common in patients with chronic kidney disease (CKD), a population at increased risk of vascular disease. We evaluated effects of allopurinol on serum XO activity and metabolome of CKD patients who...