Improved therapeutic index of an acidic pH-selective antibody

• Main Authors: Peter S. Lee (Author), Katherine G. MacDonald (Author), Evan Massi (Author), Pamela V. Chew (Author), Christine Bee (Author), Padma Perkins (Author), Bryant Chau (Author), Kent Thudium (Author), Jack Lohre (Author), Pradyot Nandi (Author), Ekaterina G. Deyanova (Author), Ishita Barman (Author), Olafur Gudmundsson (Author), Gavin Dollinger (Author), Tim Sproul (Author), John J. Engelhardt (Author), Pavel Strop (Author), Arvind Rajpal (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although therapeutically efficacious, ipilimumab can exhibit dose-limiting toxicity that prevents maximal efficacious clinical outcomes and can lead to discontinuation of treatment. We hypothesized that an acidic pH-selective ipilimumab (pH Ipi), which preferentially and reversibly targets the acidi...