Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction

• Main Authors: Mei Ying Xuan (Author), Shang Guo Piao (Author), Jun Ding (Author), Qi Yan Nan (Author), Mei Hua Piao (Author), Yu Ji Jiang (Author), Hai Lan Zheng (Author), Ji Zhe Jin (Author), Can Li (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, offers renoprotection in diabetes. However, potential for use in nondiabetic kidney disease remains unknown. Herein, we assessed whether dapagliflozin alleviates renal fibrosis by interfering with necroinflammation in a rat model of unilater...