Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction
Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, offers renoprotection in diabetes. However, potential for use in nondiabetic kidney disease remains unknown. Herein, we assessed whether dapagliflozin alleviates renal fibrosis by interfering with necroinflammation in a rat model of unilater...
Saved in:
Main Authors: | Mei Ying Xuan (Author), Shang Guo Piao (Author), Jun Ding (Author), Qi Yan Nan (Author), Mei Hua Piao (Author), Yu Ji Jiang (Author), Hai Lan Zheng (Author), Ji Zhe Jin (Author), Can Li (Author) |
---|---|
Format: | Book |
Published: |
Frontiers Media S.A.,
2022-01-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Nuclear translocation of MLKL enhances necroptosis by a RIP1/RIP3-independent mechanism in H9c2 cardiomyoblasts
by: Shoya Ino, et al.
Published: (2023) -
Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats
by: Tetsuro Marunouchi, et al.
Published: (2021) -
Macrophage Infiltration Initiates RIP3/MLKL-Dependent Necroptosis in Paclitaxel-Induced Neuropathic Pain
by: Dongyang Ma, et al.
Published: (2022) -
The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K
by: Xian-Yong Zhou, et al.
Published: (2023) -
Rip Van Winkle
by: Irving, Washington, 1783-1859; Rackham, Arthur, 1867-1939 [Illustrator]