Predictive biomarkers for response to TGF- β inhibition in resensitizing chemo(radiated) esophageal adenocarcinoma

• मुख्य लेखकों: Dajia Liu (लेखक), Amber P. van der Zalm (लेखक), Jan Koster (लेखक), Sanne Bootsma (लेखक), Cesar Oyarce (लेखक), Hanneke W.M. van Laarhoven (लेखक), Maarten F. Bijlsma (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2024-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Epithelial-mesenchymal transition (EMT) has been identified as a driver of therapy resistance, particularly in esophageal adenocarcinoma (EAC), where transforming growth factor beta (TGF-β) can induce this process. Inhibitors of TGF-β may counteract the occurrence of mesenchymal, resistant tumor cel...