Predictive biomarkers for response to TGF- β inhibition in resensitizing chemo(radiated) esophageal adenocarcinoma

• Main Authors: Dajia Liu (Author), Amber P. van der Zalm (Author), Jan Koster (Author), Sanne Bootsma (Author), Cesar Oyarce (Author), Hanneke W.M. van Laarhoven (Author), Maarten F. Bijlsma (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epithelial-mesenchymal transition (EMT) has been identified as a driver of therapy resistance, particularly in esophageal adenocarcinoma (EAC), where transforming growth factor beta (TGF-β) can induce this process. Inhibitors of TGF-β may counteract the occurrence of mesenchymal, resistant tumor cel...