Topical Administration of SLN-Based Gene Therapy for the Treatment of Corneal Inflammation by De Novo IL-10 Production

• Egile Nagusiak: Mónica Vicente-Pascual (Egilea), Itziar Gómez-Aguado (Egilea), Julen Rodríguez-Castejón (Egilea), Alicia Rodríguez-Gascón (Egilea), Elisabetta Muntoni (Egilea), Luigi Battaglia (Egilea), Ana del Pozo-Rodríguez (Egilea), María Ángeles Solinís Aspiazu (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2020-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

One of the main challenges in gene therapy is the issue of delivery, and it is especially relevant for the success of gene therapy in the cornea. In the present work, eye drops containing biocompatible non-viral vectors based on solid lipid nanoparticles (SLNs) as gene delivery systems to induce the...