Down regulation of NO signaling in Trypanosoma cruzi upon parasite-extracellular matrix interaction: changes in protein modification by nitrosylation and nitration.

• Main Authors: Milton Pereira (Author), Chrislaine Soares (Author), Gisele André Baptista Canuto (Author), Marina Franco Maggi Tavares (Author), Walter Colli (Author), Maria Julia M Alves (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Adhesion of the Trypanosoma cruzi trypomastigotes, the causative agent of Chagas' disease in humans, to components of the extracellular matrix (ECM) is an important step in host cell invasion. The signaling events triggered in the parasite upon binding to ECM are less explored and, t...