M2 polarization enhances silica nanoparticle uptake by macrophages

• Main Authors: Jessica eHoppstädter (Author), Michelle eSeif (Author), Anna eDembek (Author), Christian eCavelius (Author), Hanno eHuwer (Author), Annette eKraegeloh (Author), Alexandra K Kiemer (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

While silica nanoparticles have enabled numerous industrial and medical applications, their toxicological safety requires further evaluation. Macrophages are the major cell population responsible for nanoparticle clearance in vivo. The prevailing macrophage phenotype largely depends on the local imm...