Clinical Pharmacokinetic Assessment of Kratom (<i>Mitragyna speciosa</i>), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants

• Principais autores: Rakshit S. Tanna (Autor), James T. Nguyen (Autor), Deena L. Hadi (Autor), Preston K. Manwill (Autor), Laura Flores-Bocanegra (Autor), Matthew E. Layton (Autor), John R. White (Autor), Nadja B. Cech (Autor), Nicholas H. Oberlies (Autor), Allan E. Rettie (Autor), Kenneth E. Thummel (Autor), Mary F. Paine (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2022-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Increasing use of the botanical kratom to self-manage opioid withdrawal and pain has led to increased kratom-linked overdose deaths. Despite these serious safety concerns, rigorous fundamental pharmacokinetic knowledge of kratom in humans remains lacking. We assessed the pharmacokinetics of a single...