Clinical Pharmacokinetic Assessment of Kratom (<i>Mitragyna speciosa</i>), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants

• Main Authors: Rakshit S. Tanna (Author), James T. Nguyen (Author), Deena L. Hadi (Author), Preston K. Manwill (Author), Laura Flores-Bocanegra (Author), Matthew E. Layton (Author), John R. White (Author), Nadja B. Cech (Author), Nicholas H. Oberlies (Author), Allan E. Rettie (Author), Kenneth E. Thummel (Author), Mary F. Paine (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Increasing use of the botanical kratom to self-manage opioid withdrawal and pain has led to increased kratom-linked overdose deaths. Despite these serious safety concerns, rigorous fundamental pharmacokinetic knowledge of kratom in humans remains lacking. We assessed the pharmacokinetics of a single...