Clinical Pharmacokinetic Assessment of Kratom (<i>Mitragyna speciosa</i>), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants

• Hoofdauteurs: Rakshit S. Tanna (Auteur), James T. Nguyen (Auteur), Deena L. Hadi (Auteur), Preston K. Manwill (Auteur), Laura Flores-Bocanegra (Auteur), Matthew E. Layton (Auteur), John R. White (Auteur), Nadja B. Cech (Auteur), Nicholas H. Oberlies (Auteur), Allan E. Rettie (Auteur), Kenneth E. Thummel (Auteur), Mary F. Paine (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-03-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Increasing use of the botanical kratom to self-manage opioid withdrawal and pain has led to increased kratom-linked overdose deaths. Despite these serious safety concerns, rigorous fundamental pharmacokinetic knowledge of kratom in humans remains lacking. We assessed the pharmacokinetics of a single...