Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets

• Main Authors: Queenie Hui (Author), Ali Asadi (Author), Yoo Jin Park (Author), Timothy J. Kieffer (Author), Ziliang Ao (Author), Garth L. Warnock (Author), Lucy Marzban (Author)
• Format: Book
• Published: Elsevier, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: β-cell dysfunction and apoptosis associated with islet inflammation play a key role in the pathogenesis of type 2 diabetes (T2D). Growing evidence suggests that islet amyloid, formed by aggregation of human islet amyloid polypeptide (hIAPP), contributes to islet inflammation and β-cell d...