Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage

• Main Authors: Di Wang (Author), Danting Li (Author), Yuxin Zhang (Author), Jie Chen (Author), Ying Zhang (Author), Chuyao Liao (Author), Siyuan Qin (Author), Yuan Tian (Author), Zunjian Zhang (Author), Fengguo Xu (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intestinal toxicity induced by chemotherapeutics has become an important reason for the interruption of therapy and withdrawal of approved agents. In this study, we demonstrated that chemotherapeutics-induced intestinal damage were commonly characterized by the sharp upregulation of tryptophan (Trp)...