A novel biosensor based on intestinal 3D organoids for detecting the function of BCRP

• Main Authors: Lei Zhang (Author), Junfang Zhao (Author), Chenmeizi Liang (Author), Mingyao Liu (Author), Feng Xu (Author), Xin Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Breast cancer resistance protein (BCRP), a key drug efflux transporter, significantly affects the therapeutic efficacy of many drugs. Thus, screening specific BCRP inhibitors and distinguishing between substrates and non-substrates of BCRP are valuable in drug discovery and development. This study p...