A pipeline for identifying guide RNA sequences that promote RNA editing of nonsense mutations that cause inherited retinal diseases

• Main Authors: Nina Schneider (Author), Ricky Steinberg (Author), Amit Ben-David (Author), Johanna Valensi (Author), Galit David-Kadoch (Author), Zohar Rosenwasser (Author), Eyal Banin (Author), Erez Y. Levanon (Author), Dror Sharon (Author), Shay Ben-Aroya (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adenosine deaminases acting on RNA (ADARs) are endogenous enzymes catalyzing the deamination of adenosines to inosines, which are then read as guanosines during translation. This ability to recode makes ADAR an attractive therapeutic tool to edit genetic mutations and reprogram genetic information a...