The Effects of Combined Therapy With Metformin and Hydroxypropyl-β-Cyclodextrin in a Mouse Model of Niemann-Pick Disease Type C1

• Main Authors: Jiang Du (Author), Xinlei Liu (Author), Yan Zhang (Author), Xiaojing Han (Author), Chunya Ma (Author), Yanli Liu (Author), Lihong Guan (Author), Liang Qiao (Author), Juntang Lin (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Fag: article
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Niemann-Pick disease type C1 (NPC1) is a neurodegenerative disorder characterized by lysosomal storage of free cholesterol. 2-Hydroxypropyl-β-cyclodextrin (HPβCD) is a cyclic oligosaccharide derivative that is being developed to treat NPC1. Recently, metformin was reported to be beneficial in variou...