Insulin-Like Growth Factor-I as an Effector Element of the Cytokine IL-4 in the Development of a Leishmania major Infection

• Main Authors: Luiza C. Reis (Author), Eduardo Milton Ramos-Sanchez (Author), Fabricio Petitto-Assis (Author), Audun H. Nerland (Author), Maria Hernandez-Valladares (Author), Frode Selheim (Author), Lucile Maria Floeter-Winter (Author), Hiro Goto (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Certain cytokines modulate the expression of insulin-like growth factor- (IGF-) I. Since IL-4 and IGF-I promote growth of the protozoan Leishmania major, we here addressed their interaction in downregulating the expression of Igf-I mRNA using small interfering RNA (siRNA) in Leishmania major-infecte...