SIRT1-Dependent Upregulation of Antiglycative Defense in HUVECs Is Essential for Resveratrol Protection against High Glucose Stress

• Main Authors: Silvano Junior Santini (Author), Valeria Cordone (Author), Mahmut Mijit (Author), Virginio Bignotti (Author), Pierpaolo Aimola (Author), Vincenza Dolo (Author), Stefano Falone (Author), Fernanda Amicarelli (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Uncontrolled accumulation of methylglyoxal (MG) and reactive oxygen species (ROS) occurs in hyperglycemia-induced endothelial dysfunction associated with diabetes. Resveratrol (RSV) protects the endothelium upon high glucose (HG); however, the mechanisms underlying such protective effects are still...