The Translational Landscape Revealed the Sequential Treatment Containing ATRA plus PI3K/AKT Inhibitors as an Efficient Strategy for AML Therapy

• Main Authors: Ke Wang (Author), Ziyao Ou (Author), Ge Deng (Author), Shufang Li (Author), Jingjing Su (Author), Yayun Xu (Author), Renpeng Zhou (Author), Wei Hu (Author), Feihu Chen (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study aimed to better understand the possibility of utilizing all-trans retinoic acids (ATRA) in acute myeloid leukemia (AML). We found that ATRA significantly suppressed global translation and protein synthesis in AML cells. The efficacy of ATRA in treating AML required its translationa...