Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

• Main Authors: Sabine Specht (Author), Kenneth M Pfarr (Author), Sandra Arriens (Author), Marc P Hübner (Author), Ute Klarmann-Schulz (Author), Marianne Koschel (Author), Sonja Sternberg (Author), Coralie Martin (Author), Louise Ford (Author), Mark J Taylor (Author), Achim Hoerauf (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Filarial parasites can be targeted by antibiotic treatment due to their unique endosymbiotic relationship with Wolbachia bacteria. This finding has led to successful treatment strategies in both, human onchocerciasis and lymphatic filariasis. A 4-6 week treatment course using doxycycline results in...