Olanzapine Ameliorates Ischemic Stroke-like Pathology in Gerbils and H₂O₂-Induced Neurotoxicity in SH-SY5Y Cells via Inhibiting the MAPK Signaling Pathway

• Main Authors: Md Sadikul Islam (Author), Ha-Young Shin (Author), Yeo-Jin Yoo (Author), Ryunhee Kim (Author), Young-Jin Jang (Author), Md Rashedunnabi Akanda (Author), Hyun-Jin Tae (Author), In-Shik Kim (Author), Dongchoon Ahn (Author), Byung-Yong Park (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Olanzapine (OLNZ) is used to treat psychotic disorders. To look into the neurological basis of this phenomenon, we investigated the neuroprotective effects of OLNZ in gerbils and SH-SY5Y cells. Gerbils were subjected to transient global cerebral ischemia (TGCI) by blocking both common carotid arteri...