Administration of FTY720 during Tourniquet-Induced Limb Ischemia Reperfusion Injury Attenuates Systemic Inflammation

• Main Authors: Anthony D. Foster (Author), Diego Vicente (Author), Jonathan J. Sexton (Author), Luke Johnston (Author), Nick Clark (Author), Crystal Leonhardt (Author), Eric A. Elster (Author), Thomas A. Davis (Author), Matthew J. Bradley (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute ischemia-reperfusion injury (IRI) of the extremities leads to local and systemic inflammatory changes which can hinder limb function and can be life threatening. This study examined whether the administration of the T-cell sequestration agent, FTY720, following hind limb tourniquet-induced ske...