Epoxymicheliolide directly targets histone H2B to inhibit neuroinflammation via recruiting E3 ligase RNF20

• Main Authors: Shu-Ze Zheng (Author), Xiao-Wen Zhang (Author), Xiao-Min Song (Author), Zhuo Yang (Author), Lu Yao (Author), Peng-Fei Tu (Author), Ke-Wu Zeng (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoubiquitination plays a critical role as one of the largest histone post-translational modifications (PTMs). Recent study has revealed that histone H2B monoubiquitination (H2Bub1) at a unique lysine 120 (K120) is widely involved in the development of inflammation progression. However, small-molec...