Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway

• Main Authors: Yanfang Liang (Author), Qianqian Chen (Author), Wenjing Du (Author), Can Chen (Author), Feifei Li (Author), Jingying Yang (Author), Jianyu Peng (Author), Dongping Kang (Author), Bihua Lin (Author), Xingxing Chai (Author), Keyuan Zhou (Author), Jincheng Zeng (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epstein-Barr virus-induced gene 3 (EBI3) is a member of the interleukin-12 (IL-12) family structural subunit and can form a heterodimer with IL-27p28 and IL-12p35 subunit to build IL-27 and IL-35, respectively. However, IL-27 stimulates whereas IL-35 inhibits antitumor T cell responses. To date, lit...