A new gestational diabetes mellitus model: hyperglycemia-induced eye malformation via inhibition of Pax6 in the chick embryo

• Main Authors: Shi-Jie Zhang (Author), Yi-Fang Li (Author), Rui-Rong Tan (Author), Bun Tsoi (Author), Wen-Shan Huang (Author), Yi-Hua Huang (Author), Xiao-Long Tang (Author), Dan Hu (Author), Nan Yao (Author), Xuesong Yang (Author), Hiroshi Kurihara (Author), Qi Wang (Author), Rong-Rong He (Author)
• Format: Book
• Published: The Company of Biologists, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gestational diabetes mellitus (GDM) is one of the leading causes of fetal malformations. However, few models have been developed to study the underlying mechanisms of GDM-induced fetal eye malformation. In this study, a high concentration of glucose (0.2 mmol per egg) was injected into the air sac o...