Aromatic sulphonamides of aziridine-2-carboxylic acid derivatives as novel PDIA1 and PDIA3 inhibitors

• Main Authors: D. Zelencova-Gopejenko (Author), V. Andrianov (Author), I. Domracheva (Author), I. Kanepe-Lapsa (Author), M. Milczarek (Author), M. Stojak (Author), K. Przyborowski (Author), F. A. Fedak (Author), M. Walczak (Author), K. Kramkowski (Author), J. Wietrzyk (Author), S. Chlopicki (Author), I. Kalvins (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we report a series of newly synthesised sulphonamides of aziridine-2-carboxylic acid (Az-COOH) ester and amide analogues as potent protein disulphide isomerase (PDI, EC 5.3.4.1) inhibitors. The inhibitory activity on PDI was determined against recombinant human PDIA1 and PDIA3 protein...