Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway.

• 主要な著者: Alessandra Ricciardi (著者), Sasisekhar Bennuru (著者), Sameha Tariq (著者), Sukhbir Kaur (著者), Weiwei Wu (著者), Abdel G Elkahloun (著者), Anush Arakelyan (著者), Jahangheer Shaik (著者), David W Dorward (著者), Thomas B Nutman (著者), Roshanak Tolouei Semnani (著者)
• フォーマット: 図書
• 出版事項: Public Library of Science (PLoS), 2021-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

We have previously shown that the microfilarial (mf) stage of Brugia malayi can inhibit the mammalian target of rapamycin (mTOR; a conserved serine/threonine kinase critical for immune regulation and cellular growth) in human dendritic cells (DC) and we have proposed that this mTOR inhibition is ass...