Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway.

• Main Authors: Alessandra Ricciardi (Author), Sasisekhar Bennuru (Author), Sameha Tariq (Author), Sukhbir Kaur (Author), Weiwei Wu (Author), Abdel G Elkahloun (Author), Anush Arakelyan (Author), Jahangheer Shaik (Author), David W Dorward (Author), Thomas B Nutman (Author), Roshanak Tolouei Semnani (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously shown that the microfilarial (mf) stage of Brugia malayi can inhibit the mammalian target of rapamycin (mTOR; a conserved serine/threonine kinase critical for immune regulation and cellular growth) in human dendritic cells (DC) and we have proposed that this mTOR inhibition is ass...